The Port Muhammad Bin Qasim (Urdu: بندر گاہ محمد بن قاسم‎ Bandar-gāh Muhammad bin Qāsim), also known as Port Qasim, is a deep-water seaport in Karachi, Sindh, Pakistan, on the coastline of the Arabian Sea. It is Pakistan's second busiest port, handling about 35% of the nation's cargo (17 million tons per annum). Port Qasim and Karachi Port, the busiest port of country, together handle more than 90% of all external trade of Pakistan.

The port encompasses a total area of 12,000 acres (49 km2) wherein many industrial zones operate. In addition to the Pakistan Steel Mills (PSM) and KESC Bin Qasim Power Plant, around 80% of the Pakistan's automotive industry is located at Port Qasim. The port also provides direct waterfront access to two major nearby industrial areas, Export Processing Zone (Landhi) and Korangi Industrial Area. Approximately 60% of country's export and import is originated from these areas. Port Qasim is managed by Port Qasim Authority, a semi-autonomous government body.

Country’s first Integrated Cargo Container Control (IC3) facility is being constructed at Port Qasim with a joint investment of at over US$ 8 million.